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In a multicenter randomized controlled trial, 306 deceased donors were randomized to receive corticosteroids (1000 mg of methylprednisolone) or placebo prior to organ procurement: the rate of biopsy-proved rejection at 3 months as well as 5-year graft survival did not significantly differ between the pre-treated and placebo groups, suggesting that this approach did not impact on long-term clinical outcomes (137)

This heterogeneity is not only a hallmark of the disease but also a critical factor in determining the efficacy of treatments, including selenium supplementation

People with low glutathione levels or those with less efficient detoxification genes are at a higher risk of developing the associated diseases

Other methods of targeting aSYN concentrate on extracellular aSYN binding sites, inhibitors of aSYN aggregation, or promoters of aSYN clearance via the LAS, although they have not yet advanced to the stage of clinical development