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When mitochondrial depolarization and proteasome-dependent rupture of the outer membrane occur, PHB2 binds the autophagosome membrane-associated protein LC3 via the LC3 interaction region structural domain (Fig

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CD38: This enzyme degrades NAD+ and increases in activity with age, contributing to the age-related NAD+ decline

Mishra N, Paudel S, Agarwal C, et al