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Protective effects of black seed against chemical induced neurotoxicity Metals Lead (Pb) Treatment with lead causes wide spectrum of histopathological brain damages in rats includings degeneration of endothelial lining of brain blood vessels with perivascular cuffing of mononuclear cells consistent to lymphocytes, congestion of choroid plexus blood vessels, ischemic brain infarction, chromatolysis and neuronal degeneration, microglial reaction and neuronophagia, degeneration of hippocampal and cerebellar neurons and axonal demyelination

Clinical trials in humans indicate NMN may improve metabolic health, insulin sensitivity, and physical performance, but research is ongoing and long-term benefits in large populations are still being studied

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