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The mutant exhibited a 7 day earlier flowering time than the WT, with mean days to flowering of 44.1 and 51.1 days, respectively (Fig

Thus, GPx4 activity is a central molecular switch in the ferroptosis pathway, and the System XcGSH-GPx4 axis is also a central pathway in the ferroptosis pathway, in which a key member, inhibitory SLC7A11 (solute carrier family 7 member 11), inactivates GPx4 and increases lethal reactive oxygen species by blocking the entry of cysteine into the cell, thereby reducing GSH synthesis and ultimately inducing ferroptosis

rhamnosus GG are among the most widely researched and are frequently associated with successful clinical outcomes for these indications

Also, mTORC1 activate GLS through S6K1/eIF4B-dependent mRNA translation of c-myc , leading to GLS expression by repressing miR-23a/b [20,95]