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10.1096/fj.10-163253 33 PerrettiM.DuncanG

Another frequently described pattern of administration is cycling, which consists of alternating periods of steroid use and abstinence

USA 109 , E2533E2542 (2012)

Although all three organelles are equipped with redox-preserving defense mechanisms, ROS are thought to rapidly diffuse across membranes via certain aquaporins or other specific proteinaceous channels leading to fateful accumulations of these signaling molecules in the proximity of the three organelles 30,31 , as well as potentially lipid droplets 32

Importantly, both aPDT and laser applications face translational barriers related to equipment costs, operator training, standardization of energy parameters, and demonstration of longterm clinical superiority over mechanical debridement alone