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While the sample is small (6 patients), it represents an important step in the evidence chain: moving from laboratory proof-of-concept to human clinical testing

(90) Overall, these studies demonstrate that CDs are a promising NP platform for enhanced BBB permeation through passive diffusion

518,519,520,521 Hepatocellular carcinoma (HCC) Initially developed for treating diabetes, GLP-1RAs have shown potential in treating NASH, which is closely related to HCC

[DOI] [PubMed] [Google Scholar] 71.Zhang H., Shi Q., Nan W., Wang Y., Wang S., Yang F., Li G

Intracellularly, the Fenton reaction is limited, in part, by the lack of free transition metals in cells, but may play a role in oxidative damage after ischemia-reperfusion or under other oxidative stress conditions that involve accumulation of high levels of intracellular hydrogen peroxide and liberation of Fe 2+ from intracellular storage sites (115, 288)