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The ongoing development of new XO inhibitors remains critically important due to welldocumented limitations of existing therapies, including adverse effects, the emergence of resistance, interindividual variability in therapeutic responses, and the requirement for high therapeutic doses, as seen with allopurinol

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However, these parameters only detect functional impairment after significant renal damage has occurred, highlighting the need for more sensitive early biomarkers [5]

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[DOI] [PubMed] [Google Scholar] 124.Thaut M, Kenyon G, Hurt C, McIntosh G, Hoemberg V