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ROS induces epithelial-mesenchymal transition via the TGF-beta1/PI3K/Akt/mTOR pathway in diabetic nephropathy

& Gatz, C

Under hypoxic conditions, the stabilization of the HIF-1 protein occurs, leading to the translocation of the HIF-1 complex into the nucleus, which activates target genes crucial for cellular proliferation, survival, and differentiation (17, 62)

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Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis