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For example, HFD has a negative effect on gut integrity

423 The research further demonstrated that this anti-inflammatory effect was not mediated by GLP-1R in the blood or endothelial cells but required the GLP-1R in the CNS

& Cocking, C

Kolaczkowska, E

Moreover, NAD+ is also a key player in redox reactions, and its depletion is thought to contribute to the development of oxidative stress