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That is a remarkably narrow therapeutic window executed successfully, suggesting rapid and potent neuroprotective action

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At maintenance or surplus, you may see improved insulin sensitivity and mitochondrial function, but fat loss will be minimal without negative energy balance

It is generally recommended to take B-vitamin supplements in the morning or early afternoon, as their role in cellular energy production can sometimes have a mildly stimulating effect that might interfere with sleep if taken too late in the evening