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Multiple components of the UPS are localized to the OMM, where they ubiquitinate mitochondrial proteins that need to be extracted from the mitochondrial membrane and positioned to face the cytosol to be translocated and degraded by the proteasome 13,17

Pomegranate extract, rich in polyphenols, can reduce TMA production, potentially neutralizing the harmful effects of L-carnitine

The patient was homozygous for a microdeletion in 11p14.2, which contains the BBOX1 gene (GRCh38: 11:27,040,70427,127,806) encoding for the butyrobetaine hydroxylase enzyme, as well as the Fibin (Fin Bud Initiation Factor Homolog) gene encoding for fibin, a secreted protein identified in zebrafish, mice and humans potentially acting downstream of retinoic acid and wnt signaling, essential for pectoral fin bud initiation and tbx5 expression in zebrafish [170, 171]

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Viene scelta negli integratori perch unisce linteresse per il metabolismo energetico a un profilo apprezzato anche nei prodotti pensati per concentrazione e vitalit mentale