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[DOI] [PubMed] [Google Scholar] [5].Sierra-Rivera EDM, Summar ML, et al

The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage

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HPLC-MS/MS: high-performance liquid chromatography-tandem mass spectrometry
PMID: 42262169 J Pineal Res Melatonin Improves Diabetic-Accelerated Experimental Osteoarthritis by Inhibiting NLRP3-Mediated Chondrocyte Pyroptosis via PKG/Nrf2