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At the same time, it appears to boost macrophage activity, which might support the clean-up phase of inflammation and transition toward repair

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Serious safety concerns (immune reactions, cancer risk)

Therefore, semaglutide, tirzepatide, and retatrutide are expected to be safer and more effective treatments for MC4R-deficient obesity than setmelanotide

This makes it an appealing subject of research in metabolic health and obesity management