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So because B12 is water soluble, there is no toxicity

Therapeutic mechanisms of glucocorticoids
J Exp Bot 63:12411250 Cao Y, Ma C, Yu H, Tan Q, Dhankher OP, White JC, Xing B (2023) The role of sulfur nutrition in plant response to metal(loid) stress: facilitating biofortification and phytoremediation
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Alongside pharmacological inhibitors, natural substances like EGCG, a polyphenol present in green tea, have shown encouraging outcomes in both in vitro and in vivo models by markedly decreasing TGF-1 expression and collagen accumulation (Gao et al., 2025)
