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Nicotinic acid phosphoribosyltransferase regulates cancer cell metabolism, susceptibility to NAMPT inhibitors, and DNA repair

2024 Jun 11;46(6):5812-5824

To investigate whether the suppressive effect of Fasn inhibition on NLRP3 inflammasome-dependent pyroptosis is mediated through the reduction of ROS production, NAC, an antioxidant that eliminates ROS by promoting GSH synthesis, was used (68)

In Vivo Investigations The use of animal models is fundamental in biomedical research to advance our understanding of the pathophysiology, progression, and treatment of diseases [188]

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