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Supplementary Information The online version contains supplementary material available at 10.1186/s12916-022-02477-z

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These modifications enhance the peptide's stability and resistance to enzymatic degradation, particularly by the enzyme DPP-IV (dipeptidyl peptidase IV), thereby slightly extending its half-life compared to Sermorelin (the unmodified GHRH 1-29)

Gateways bridge DSIP NG911 where needed

(Hoboken, NJ: John Wiley & Sons) 7083
