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1 The Overview of Nuclear Factor Erythroid (NF-E2)-Related Factor 2 (Nrf2) and Nuclear Factor-Kappa B (NF-B) 1.1 The Role of Nrf2 and Its Regulation When our body is continuously exposed to external stresses, its easy to produce the excessive free radicals and reactive oxygen species (ROS) in the mitochondria, peroxisomes, and endoplasmic reticulum (ER), and downregulate endogenous antioxidants such as enzymes and antioxidant proteins (may be stress upregulated sometimes, but not enough to resist oxidative stress), thereby leading to damage of cellular components including proteins, DNA, and lipids (Tonelli et al., 2018)

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