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The increased cellular uptake of copper, combined with increased Fenton activity, can significantly increase intracellular ROS levels, thereby activating Caspase-1 proteins and pyroptosis-related genes, such as nucleotide-binding oligomerization domain-like receptor protein 3 inflammasomes and IL-1

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Ochiai B

The clinical study was performed in accordance with the World Medical Association Declaration of Helsinki, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Guideline for Good Clinical Practice (GCP) E6 (R2), the applicable regulatory requirements, and the Australian National Health and Medical Research Council National Statement on Ethical Conduct in Human Research incorporating all updates

The cis double bonds, which are necessary for the process of decorating, may be converted into cyclopropane by MmaA2 and PcaA [36, 59], or converted into a trans double bond by UmaA1 [60], or hydrated into hydroxylated mycolates by MmaA4 [53, 57, 61, 62]