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Because his Borrelia burgdorferi IgG titers were markedly elevated and he had a history of tick bites and rash, a lumbar puncture was performed

doi: 10.1158/2159-8290.CD-20-0119

Furthermore, APOE4-targeted replacement mice, carrying the human APOE4 allele (a known strong risk factor for developing late-onset AD), display significant depressive-like behaviors compared to APOE3 counterparts, especially under stress conditions (Fang et al., 2021

Wu K, Wang X, Xie Z, Liu Z, Lu Y

Some anti-depressants when used with vitamin B complex can cause panic which could be a potential effect of these vitamins on central nervous system