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In detail, activation of PKA, at precise subcellular compartments, reflects the potency and duration of -AR stimulation with a non-linear dose/effect relationship, so that at lower level of -AR activation, inotropy is enhanced, while recruitment of additional lusitropic benefit only occurs at higher -AR activation levels (Bers et al., 2019)

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10l,m), hepatic steatosis (Extended Data Fig

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