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Emerging data show that VitC is also a cofactor for newly characterised hydroxylases of the family of Fe-containing 2-oxoglutarate-dependent dioxygenases that regulate gene transcription and cell signalling pathways [3, 4]

This study highlights the importance of rare genetic variants in understanding the genetic architecture of alcohol metabolism, expanding the scope of research in potential pharmacological targets beyond common variants in ADH and ALDH

The site was tender and warm to the touch, but no disruptions in the skin barrier were noted