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Moreover, LC administrated for 2 weeks suppresses atrogin-1 messenger RNA (mRNA) level in suspended rats hindlimb [35], and only 7 days of LC administration downregulates MuRF-1 and atrogin-1 mRNAs reducing muscle wasting in a rat model of cancer cachexia [32]
References Felder S, Lechtenboehmer C, Bally M, Fehr R, Deiss M, Faessler L, et al
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In patients with treatment-resistant depression, naltrexone 50 mg blocked the antidepressant but not the dissociative effects of KET, suggesting that the opioid system may also be required for KET antidepressant activities (Williams et al., 2018)
