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By reducing ROS production, GSH inhibits NF-kB activation and consequently keeps the cytokine storm under control

Additionally, in diabetic wounds, glucose metabolism is impaired due to insulin resistance and defective glucose uptake, which exacerbates the inhibition of mitochondrial oxidative phosphorylation and glycolysis, and leads to insufficient ATP production and subsequent mitochondrial dysfunction

Biochemistry 27 , 85098515 (1988)

However, this gene encodes an enzyme with GSNO reductase activity (Sakamoto et al., 2002

and Ida Green Professorship in System Biology (to J.Z.) from the University of Texas at Dallas