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Additionally, the inhibition of mitochondrial respiration can decrease the transmembrane potential, leading to the release of cytochrome-c, which interacts with the cytoplasmic apoptosis activating factor-1 (Apaf-1) and procaspase-9 initiating the apoptotic cascade (Potoka et al., 2002)

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Dulchavsky SA, Maitra SR, Maurer J, et al

BMD declines of 5% or greater at the lumbar spine were experienced by 2% of GENVOYA subjects and 6% of subjects who continued their TDF-based regimen