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These newly formed blood vessels frequently bleed, causing the macula to bulge or form a mound, often surrounded by small hemorrhages and tissue scarring

NADH can bind to the NADH/ADP binding site and enhance the inhibitory effect of GTP on GDH activity by slowing down the release of NAD(P)H, an oxidative product of glutamate

Additional studies involving the synthesis of over-lapping peptide fragments might also provide further insight into the structure/function relationships

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