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Contrary to previous predictions, the increase of intracellular cysteine did not affect the cellular GSH pool, but concomitantly boosted extracellular cysteine concentrations

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All administrations were done orally for once

On the optical capabilities, the detecting system with PIOr-GSH exhibited the advantages including applicable linear range, high sensitivity, high steadiness in various working conditions (recognition time, pH, and incubation temperature)

For example, exposing endothelial cells to MOTS-c in vitro attenuated dysfunction caused by oxidative stress, in part by activating AMPK and suppressing inflammatory pathways (such as the MAPK/NF-B pathway) in those cells