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However, the key limitations of existing studies lie in small clinical sample sizes without multicenter validation and unstandardized intervention protocols in animal models, both of which impede clinical translation

without imaging guidance 62327 with imaging guidance (ie, fluoroscopy or CT) All even numbered codes are without imaging guidance, and all odd numbered codes are with imaging guidance

A higher 5-Amino-1MQ dosage might be necessary in subjects with advanced metabolic dysfunction to achieve a noticeable effect

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Mechanistic plausibility alone does not establish clinical benefit