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Current evidence suggests that melatonin has a mitigating effect on the ototoxicity of glyphosate-based herbicides and fenoxaprop-ethyl, and its possible mechanisms include the prevention of glyphosate-based herbicides-induced oocyte deterioration and activation of its downstream signaling events (pERK/ERK) by protecting G-protein estrogen receptor (GPER/GPR30) expression and regulating the levels of regulatory hormones (He et al., 2019a

Mendha et al

Furthermore, a pharmacokinetic study in rats showed higher brain levels after intranasal delivery of lipid sumatriptan nanoparticles compared to intravenous application [266]

Factors contributing to yield reduction under drought stress include reduced carbon metabolism, stomatal conductance, and water uptake due to impaired root growth 30

2.3.4 Brain Approximately 5%-10% of reproductive-age women without PCOS worldwide experience depression and anxiety, and 40% of women with PCOS suffer from depression (116)