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The phosphoinositide-3-kinase (PI3K)/Akt axis participates in a multitude of intracellular processes, such as those involved in protein synthesis, cell proliferation and death, and autophagy, and also in the development of drug tolerance upon stimulation by cytokines and growth factors (GFs) (84)
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Although luteolin did not bind to the binding pocket of the GPVI-specific ligand CPR, its binding site was close to the pocket of the active site (Lecut et al., 2004
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