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They'll do a physical exam to check for symptoms such as: A malar rash, the butterfly rash on your cheeks A discoid rash with red, scaly skin patches that cause scarring Photosensitivity, a skin reaction or sensitivity to sunlight Oral ulcers, open mouth sores Other symptoms could include: Arthritis, pain, inflammation, or swelling in your joints Nervous system problems, seizures, or psychosis Inflammation of the tissue around your lungs (pleuritis) or around your heart (pericarditis) Blood and urine tests can help your doctor see if you have other conditions that could be caused by lupus, including: Kidney problems, with either red blood cells or extra protein in your urine (proteinuria) A blood disorder, either a low red blood cell count (anemia), a low white blood cell count (leukopenia), fewer lymphocytes (lymphopenia), or fewer platelets (thrombocytopenia) An immunologic disorder, including certain cells or proteins, or a false-positive test for syphilis (antiphospholipid antibodies)