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In contrast, M2 polarized tumor-associated macrophages (TAMs), are associated with worse outcomes as they cause angiogenesis, ECM degradation, and metastasis (106)
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Official FDA approval requires expensive, multi-phase clinical trials
doi:10.1016/j.ejphar.2021.174622 27
10.1002/cbdv.202300847 35 BianY.ChangX.HuX.LiB.SongY.HuZ.et al (2024)
