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In normal individuals, only 10%-20% of copper is free, while in untreated WD, it represents up to 60%-80% of serum copper

In a phase II clinical trial (NCT02644369), it was found that an increase in serum choline levels (cholineC3) at week 7 in patients receiving pembrolizumab treatment was significantly associated with better progression-free survival (PFS) and showed a trend of improvement in overall survival (OS)

While there have been attempts to measure the number of CD4 + T cells in the blood of PD patients, the results remain controversial

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10.3390/nu12071935 98 FasakinO
