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This suggests that the proliferation of this metabolic resistance marker could exacerbate malaria transmission in the field and thus have important public health consequences

Thus, hypoxia-generated ROS represents a fundamental pathogenic mechanism contributing to chemoresistance [480], ischemiareperfusion injury [481], chronic inflammation [482], and neurodegeneration [483]

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The resulting phenotype from laboratory selection may have been influenced by a combination of epigenetics, de novo mutations, genetic drift, and variant selection

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