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Moreover glutaminolysis-mediated mTORC1 activation required prolyl hydroxylase (PHD) enzymatic activity in a HIF -independent manner [89]
Furthermore, the association of hypoglycemia with adverse events underscores the complexity of glycemic management, highlighting the need for strategies that mitigate hyperglycemic risk without inducing harmful glucose lows

Melanocortin antagonists are also being evaluated for the treatment of cachexia [65,66]

Genes Cancer 2 , 10611066 (2011)

therefore, treatment should be started with small doses and gradually increased
