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Endo S, Matsunaga T, Hara A

The translation of this information to the human is supported by the evidence showing that melatonin is likely an important and useful molecule to modify the course of AMD and since it is inexpensive and has a very large safety profile in terms of dose (no LD50 has been identified despite attempts to do so), it should be seriously examined as a protection against AMD

Despite considerable progress, there exist unanswered questions

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we can discuss alternatives or revisit treatment after this period