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Structural Features: Stability Optimization: Lipid chain conjugation extends in-vivo residence time (fatty acid modified peptide technology) Disulfide bridge (Cys-Cys) stabilizes 3D conformation Amino Acid Sequence: Pyr-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-OH (Disulfide bond: Cys-Cys) Reviews of Cagrilintide Key Properties of Cagrilintide 1

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& Goebel, W

This pathway makes the endothelial cells change on many levels