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The up-regulation of EGF coupled with loss of cell cycle control (both p16 INK4A and p14 ARF ) was shown to induce higher-grade glioma formation in vivo

doi: 10.1136/gutjnl-2019-318664 61 MassierLChakarounRKovacsPHeikerJT

Furthermore, rescue experiments with antioxidant N-acetylcysteine (NAC) showed that the expression of 4-HNE and the apoptosis in SGNs were significantly decreased, while the number of surviving SGNs was increased in peroxynitrite + NAC group compared the peroxynitrite-only group and in peroxynitrite + gpx1 / + NAC group vs

European Journal of Lipid Science and Technology, 114(4), 389-398