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For advanced injectables such as Profhilo, Radiesse Plus, Rejuran, or Sculptra, mild redness or swelling may occur post-treatment

10.1073/pnas.1221210110 4 AntelmannH.HeckerM.ZuberP

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The vascular microenvironment and the associated endothelial dysfunction look to predict the prognosis of the lesions

So unless its being used up in 1-2 days max, you should not add water to it!) The point is to dilute the acidity to a point that it will no longer cause tissue necrosis (death/damage) or pain upon injection