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Besides the role in oxidative stress response, many fungal Gst encoding genes are also upregulated in response to heavy metals, xenobiotics, or other stress conditions

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Its pathogenesis is influenced by familiar history, genetic susceptibility, and environmental and metabolic factors

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If deficiency is left uncorrected over months or years, more serious neurological symptoms can develop: numbness or tingling in the hands and feet, problems with balance and coordination, memory lapses, and tongue soreness