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doi: 10.1126/scisignal.abm6265 120 YaoFDengYZhaoYMeiYZhangYLiuXet al
It is important to acknowledge that the current body of research is largely confined to cell cultures and animal models
The cysteine S -conjugate of busulfan (-( S -tetrahydrothiophenium)-l-alanine, THT-A) is unusual in that the sulfur is in the oxidation state of a sulfonium rather than a thioether
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Although this mechanism has not yet been systematically validated in tumors, it provides a theoretical framework for exploring RvE1s role in maintaining vascular homeostasis within the tumor microenvironment (TME)
