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N Engl J Med 310 : 810815 Baxter RC (1995) Insulin-like growth factor binding proteins as glucoregulators

Conditions involving intestinal inflammation, barrier dysfunction, or ulceration may respond to the peptide reparative effects, particularly when administered orally for direct tissue contact

Factors contributing to this decline include: Increased activity of NAD+-consuming enzymes (like PARPs, which work overtime to repair accumulated DNA damage)

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For Genetic B12 Malabsorption Some genetic conditions cause the digestive system to be unable to break down the vitamin B12 in the body
