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doi: 10.1016/s0016-5085(85)80176-1

Recently, despite a lack of significant association between hyperhomocysteinemia and the risk of venous thromboembolism, in a prospective study of patients with systemic lupus erythematosus, Petri et al (1996) report that hyperhomocysteinemia, defined as total plasma homocysteine concentrations higher than 14.1 mol/L, is significantly associated with arterial thrombotic events (odds ratio 3.74), and stroke (odds ratio 2.24)

The Role of Oxidative Damage in the Pathogenesis and Progression of Alzheimers Disease and Vascular Dementia

For most healthy adults, 1500 mcg is generally not considered dangerous
