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As a demonstration of epitope mapping with CSOP, we examined antibodies targeting CD45 a transmembrane tyrosine phosphatase whose exclusion from membrane interfaces plays a critical role in immune cell activation (40, 41) (Fig

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253 5-HTP has been shown to raise serotonin levels and activity in humans, 254 and one study found women with fibromyalgia had lower levels of 5-HTP and serotonin than matched controls
