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This interaction leads to the formation of protein carbonyls and disulfide bonds, which alter the proteins structure and function

10.1080/15376516.2020.1747125 151 ZhangC.JiaX.BaoJ.ChenS.WangK.ZhangY.et al (2016)

The main bioactive component of silymarin was first identified by Pelter and Hnsel in 1968, and in the 1970s, the WHO approved milk thistle extract as a recognized treatment for liver-related diseases

2a), indicating that at least a portion of food-derived glutathione is degraded by -glutamyltransferase or other peptidases (either circulating freely in the blood or on the surface of cell membranes) during blood circulation