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In order to restore the tissues integrity, not only do resident stem cells have to be activated, but also some differentiated cells must revert to a stem cell-like state and acquire mobility

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For example, a core-shell particle system was constructed by polymerization of tetraethyl orthosilicate grafting on magnetic Fe 3 O 4 nanoparticles for both drug delivery and magnetic resonance imaging

For example, the proinflammatory cytokine tumor necrosis factor alpha (TNF) can directly increase intestinal permeability in cultured intestinal epithelial cells and mouse epithelium by dysregulating TJ proteins