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Journal of Cancer Research and Clinical Oncology

G., Petersen C

doi: 10.1016/s0303-7207(98)00068-9

In addition, 4-chloropyridine 10 and 4-chloronicotinamide 11 were reported to be suicide substrates as they can be N -methylated by NNMT and subsequently react with C159 to inactivate NNMT with k obs /[I] values of 20 M 1 min 1 and 80 M 1 min 1 , respectively

First, they found that glucose production, G6pc expression, and Pck1 expression were significantly lower in NNMT -overexpressing hepatocytes with Sirt1 inhibition than in NNMT -overexpressing hepatocytes without Sirt1 inhibition and that Sirt1 overexpression rescued the suppression of G6pc expression and Pck1 expression induced by NNMT knockdown [14]