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When a patient self-administers a product that was stored improperly or misdosed, the side effect profile changes entirely and not in a predictable way

The lack of effect on dopamine transmission with other types of antidepressants may be a possible cause of residual symptoms such as impaired motivation, concentration, and pleasure, even in patients who initially respond to other antidepressants

Patients with certain genotypes may experience faster satiety onset or require different dose titration patterns

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184 : 23992404 Eguchi Y, Shimizu S and Tsujimoto Y (1997) Intracellular ATP levels determine the cell death fate by apoptosis or necrosis