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AOD-9604 was advanced through Phase I and Phase II clinical trials by Metabolic Pharmaceuticals between roughly 2003 and 2007 enrolling approximately 900 participants in total

S1 nerve compression causes pain down the back of the leg to the heel, with potential weakness in plantar flexion (pushing off with the toes)

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The effect is particularly noticeable in poorly vascularized tissues like tendons, which normally heal slowly due to limited blood flow

cautious use of the ophthalmic solution is advised with ocular surgery (3, 5)