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We further identified type I interferon (IFN-I) signaling as a key upstream regulator that induces Chac2 expression and drives metabolic reprogramming

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Moreover, overexpression of five GST isozymes reduced the release of lactate dehydrogenase and reactive oxygen species by 8.8%64.4%, and 57.2%77.6%, respectively, as well as enhanced the production AFBO-GSH by 15.8%19.6%, thus mitigating DNA damage induced by AFB1

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