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Increases in GSSG relative to GSH are a useful indicator of oxidative stress or disulfide stress (slund and Beckwith, 1999), and in plants can be observed in response to conditions such as ozone, pathogens, and cold, as well as deficiency in important H 2 O 2 -metabolizing enzymes such as catalase and ascorbate peroxidase (APX

In cellular and animal models of steroid insensitivity mediated by oxidative stress, S-CMC restored steroid sensitivity by increasing HDAC-2 expression/activity through elevating GSH and SOD levels, reducing oxidative stress, enhancing HDAC-2 recruitment and reducing H4 acetylation in the IL-8 promoter region, and eventually alleviating inflammation and lung damage [88, 89]

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This review focuses on the redox balance between ROS production and antioxidant defense systems, discussing proposed therapeutic strategies for the development and progression of human cancer, especially ovarian cancer